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Diabetic Neuropathy Link Share

Overview

Diabetic neuropathy is a type of nerve damage that can occur if you have diabetes. High blood sugar (glucose) can injure nerves throughout your body. Diabetic neuropathy most often damages nerves in your legs and feet.

Depending on the affected nerves, symptoms of diabetic neuropathy can range from pain and numbness in your legs and feet to problems with your digestive system, urinary tract, blood vessels and heart. Some people have mild symptoms. But for others, diabetic neuropathy can be quite painful and disabling.

https://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/symptoms-causes/syc-20371580

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Paleo Diet~Ooooh!

Risks for heart disease, study implies…

ANI | Aug 8, 2019

People who follow paleo diet

 were found to have twice the amount of a key blood biomarker that is linked closely to heart diseases, suggests a study.

The study published in the ‘European Journal of Nutrition’ examined the impact of the diet on gut bacteria.

Researchers compared 44 people on the diet with 47 following a traditional Australian diet. They measured the amount of trimethylamine-n-oxide (TMAO) in participants’ blood. High levels of TMAO, an organic compound produced in the gut, are associated with an increased risk of heart disease.

The controversial Paleo (or ‘caveman’) diet advocates eating meat, vegetables, nuts and limited fruit, and excludes grains, legumes, dairy, salt, refined sugar and processed oils.

Dr Angela Genoni, the lead researcher said that with the diet’s growing popularity, it was important to understand the impact it could have on overall health.

“Many Paleo diet proponents claim the diet is beneficial to gut health, but this research suggests that when it comes to the production of TMAO in the gut, the Paleo diet could be having an adverse impact in terms of heart health,” she said.

“We also found that populations of beneficial bacterial species were lower in the Paleolithic groups, associated with the reduced carbohydrate intake, which may have consequences for other chronic diseases over the long term.”

She said the reason TMAO was so elevated in people on the Paleo diet appeared to be the lack of whole grains in their diet.

“We found the lack of whole grains were associated with TMAO levels, which may provide a link between the reduced risks of cardiovascular disease we see in populations with high intakes of whole grains,” she said.

The researchers also found higher concentrations of the bacteria that produce TMAO in the Paleo group.

“The Paleo diet excludes all grains and we know that whole grains are a fantastic source of resistant starch and many other fermentable fibres that are vital to the health of your gut microbiome,” Dr Genoni said.

“Because TMAO is produced in the gut, a lack of whole grains might change the populations of bacteria enough to enable higher production of this compound.

“Additionally, the Paleo diet includes greater servings per day of red meat, which provides the precursor compounds to produce TMAO, and Paleo followers consumed twice the recommended level of saturated fats, which is cause for concern,” she said.

https://m.timesofindia.com/life-style/health-fitness/diet/paleo-diet-may-increase-risk-of-heart-disease-study/amp_articleshow/70589140.cms

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Signs That Could Indicate Heart Disease/Information Share

https://www.msn.com/en-us/health/healthy-heart/six-unusual-signs-that-may-indicate-heart-disease/ar-AAveu74?ocid=spartandhp

1. Creased earlobes

One such external indicator is diagonal creases on the earlobes — known as Frank’s sign, named after Sanders Frank, an American doctor who first described the sign. Studies have shown that there is an association with the visible external crease on the earlobe and increased risk of atherosclerosis, a disease where plaque builds up inside your arteries.

Over 40 studies have demonstrated an association between this feature of the ear and an increased risk of atherosclerosis. It is not clear what the cause of the association is, but some have postulated that it is to do with a shared embryological origin. Most recently, it has been seen that these creases are also implicated in cerebrovascular disease — disease of the blood vessels in the brain.

2. Fatty bumps

Another external indicator of heart issues is yellow, fatty bumps — known clinically as “xanthomas” — that can appear on the elbows, knees, buttocks or eyelids. The bumps themselves are harmless, but they can be a sign of bigger problems.

close up of arcus senilis during ophthalmic examination. © ARZTSAMUI/Shutterstock close up of arcus senilis during ophthalmic examination.

Xanthomas are most commonly seen in people with a genetic disease called familial hypercholesterolemia. People with this condition have exceptionally high levels of low-density lipoprotein cholesterol — so-called “bad cholesterol”. The levels of this cholesterol are so high they become deposited in the skin. Unfortunately, these fatty deposits are also laid down in arteries that supply the heart.

The mechanism that causes these fatty deposits in tissues is understood and it holds an iconic place in medicine as it led to the development of one of the blockbuster group of drugs that reduce cholesterol: statins.

3. Clubbed fingernails

A phenomenon known as digital clubbing may also be a sign that all is not well with your heart. This is where the fingernails change shape, becoming thicker and wider, due to more tissue being produced. The change is usually painless and happens on both hands.

The reason this change indicates heart issues is because oxygenated blood is not reaching the fingers properly and so the cells produce a “factor” that promotes growth to try and rectify the issue.

Clubbing of the fingers is the oldest known medical symptom. It was first described by Hippocrates in the fifth-century BC. This is why clubbed fingers are sometimes known as Hippocratic fingers.

4. Halo around the iris

Fat deposits may also be seen in the eye, as a grey ring around the outside of the iris, the coloured part of the eye. This so-called “arcus senilis”, starts at the top and bottom of the iris before progressing to form a complete ring. It doesn’t interfere with vision.

About 45% of people over the age of 40 have this fatty halo around their iris, rising to about 70% of people over the age of 60. The presence of this fatty ring has been shown to be associated with some of the risk factors for coronary heart disease.

5. Rotten gums and loose teeth

The state of your oral health can also be a good predictor of the state of your cardiovascular health. The mouth is full of bacteria, both good and bad. The “bad” bacteria can enter the bloodstream from the mouth and cause inflammation in the blood vessels, which can lead to cardiovascular disease.

Studies have shown that tooth loss and inflamed gums (periodontitis) are markers of heart disease.

6. Blue lips

Another health indicator from the mouth is the colour of your lips. The lips are usually red, but they can take on a bluish colour (cyanosis) in people with heart problems, due to the failure of the cardiovascular system to deliver oxygenated blood to tissues.

Of course, people also get blue lips if they are extremely cold or have been at a high altitude. In this case, blue lips are probably just due to a temporary lack of oxygen and will resolve quite quickly.

In fact, the other five symptoms — mentioned above — can also have a benign cause. But if you are worried or in doubt, you should contact your GP or other healthcare professional for an expert opinion.

Adam Taylor is director of the Clinical Anatomy Learning Centre and a senior lecturer at Lancaster University.

© ARZTSAMUI/Shutterstock close up of arcus senilis during ophthalmic examination.
Xanthomas are most commonly seen in people with a genetic disease called familial hypercholesterolemia. People with this condition have exceptionally high levels of low-density lipoprotein cholesterol — so-called “bad cholesterol”. The levels of this cholesterol are so high they become deposited in the skin. Unfortunately, these fatty deposits are also laid down in arteries that supply the heart.
The mechanism that causes these fatty deposits in tissues is understood and it holds an iconic place in medicine as it led to the development of one of the blockbuster group of drugs that reduce cholesterol: statins.

Thank you for reading 🙂

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