Taming chronic inflammation starts with what you put on the end of your fork. In other words, your best defense to fight inflammation starts with your very next meal or snack. Researchers find that a pro-inflammatory diet significantly increases weight gain and your risk for being overweight or obesity.

The best way to shift that balance is to eat fewer inflammatory foods and much more anti-inflammatory food. The latter include wild-caught fish, loads of nonstarchy vegetables, low-sugar fruit like berries and avocado, raw nuts and seeds, and cultured and fermented foods. Stop and consider, for instance, that our ancestors ate nearly an equal ratio of omega-3 and omega-6 fatty acids—whereas today we are eating 20 times (sometimes higher) of inflammatory omega-6 fatty acids. We’re eating fewer anti-inflammatory foods, but the inflammatory ones we consume (sometimes from not-so-obvious sources like almond milk or factory-raised eggs) can crowd out the healthy ones.

Take soybean oil, prevalent in pretty much any restaurant you eat, which can decrease the amounts of the anti-inflammatory fatty acids EPA and DHA. Even if you’re avoiding the usual suspects like sugar, gluten, and other high-sensitivity foods I often talk about, inflammatory foods can be slipping into your diet. Grain-fed meats, vegetable oils, roasted nuts and seeds, and pretty much any processed food in your grocery store fuels inflammation.

You cannot fix inflammation without fixing the gut. When your gut lining is disturbed, it cannot absorb nutrients optimally and inflammation develops. Eventually problems like leaky gut lead to food sensitivities and even autoimmune disease.

A downward spiral occurs as gut inflammation becomes systemic (or full-body) inflammation, creating pain, headaches, and other symptoms that you might never suspect originated in your gut.

Healing gut inflammation requires time and patience. The right protocol eliminates food sensitivities, incorporates plenty of anti-inflammatory foods, and includes gut-supporting nutrients like L-glutamine, probiotics, and prebiotics. Here’s a three-day plan to get you started.

If you’re not eating an anti-inflammatory diet and incorporating other lifestyle strategies delineated here, taking supplements that can lower inflammation won’t help much.

But combined with the right diet, supplements can help tame inflammation. Among the favorites I use in my practice daily are:

Many of the over 80,000 chemicals we are exposed to daily have not been tested for human safety. They are everywhere: in our furniture as fire retardants, in cosmetics as heavy metals, in our household cleaners as emulsifiers, and in our food as preservatives. These toxins create all sorts of problems. They disrupt our hormonal balance, keep our immune system revved up, and increase our risk for diseases including cancer and autoimmune disease. Chronic inflammation plays a role in all of these problems.

Just like we are all inflamed, we are all toxic. To reduce that toxic load, you’ll want to minimize the toxins you’re exposed to daily that are under your control.

That might mean becoming more mindful about what cosmetics you use, what household cleaners you keep around, and what skin products you spread on your body, as well as drinking clean, filtered water, eating mostly organic plant foods, and if you are a meat eater, mainly consuming clean protein sources like pasture-raised meats.

You’ll also want to eat plenty of detoxifying foods, including leafy and cruciferous greens, along with spices like turmeric. Once or twice a year, consider working with a professional to incorporate a plan that provides your cells the nutrients they require to optimize detoxification. And a gut cleanse is a great way to clean out the pipes and dump some of those accumulated toxins.

Research shows that regular exercise protects against chronic low-grade systemic inflammation present in diseases, such as type 2 diabetes and cardiovascular disease. I like to use the word “movement” as opposed to “exercise” because movement encompasses a broader array of activities.

Yours might include yoga, brisk walking, or weight resistance exercises. Research shows high-intensity interval training, which is fast and effective, can reduce the inflammation that contributes to disease like cancer. But remember this—if you’re a CrossFitter or do any high-intensity exercise, then stock up on the anti-inflammatory nutrients I mentioned above. Moderate exercise reduces inflammation, but extreme exercise (like marathon training and Tough Mudders) will increase inflammation.

The important thing is that you do something that challenges your body without abusing its limits.

Stress is a major and underestimated factor that affects inflammation, even when all other lifestyle behaviors (like diet and exercise) are on point.

Stress increases inflammation, regardless of how good you’re being with your diet. It activates the fight-or-flight response that makes you feel like you’re under attack when you’re not. It can lead to elevated blood pressure, palpitations, and reduced blood flow to the intestines, resulting in poor digestion and assimilation of nutrients.

Some of my patients live under and handle such elevated levels of stress on a daily basis they consider it normal. They have become desensitized to the thought of stress, but their bodies have not been desensitized to the ravages of stress. Essentially, they’ve ceased to notice what a huge impact stress has on their lives. I often point out to my patients how full their plates are and how even if the load they carry (between work and social life) feels “normal,” it shouldn’t be their “normal.”

Forty percent of Americans get less than the seven hours of recommended sleep per night. When compared to the amount of sleep Americans got in 1942, we are getting one hour less per night. That’s outstanding considering modern technology should be making our lives easier, not harder. The problem is the health ramifications of sleep deprivation.

Studies support what I see regularly in my practice: Sleep deprivation can trigger or exacerbate inflammation. Multiple mechanisms are at work here. Sleep loss adversely alters the body’s inflammatory markers, but then you are more prone to make unwise food choices, fuel up on caffeine to get through the morning, and feel more stressed throughout your day with less sleep. Keeping inflammation under control requires eight to nine hours of solid, uninterrupted sleep every night.

Sleep hygiene is important. At least one hour before bedtime, shut down your electronics, block out sleep-disrupting blue light by putting on your blue-spectrum-blocking glasses, dim the lights, and pull up a good book to read (on paper).